Quite a lot has already been written about this, so I won’t repeat it.
Here’s a working rule for Safari tested with the AdBlock extension v2.70, that will leave you on a blank screen at the end of a video.
Adblock rules for Safari:
Regardless of your ‘auto play’ setting, Amazon Prime Video displays a “Next Up” box bottom right, with movie artwork, on reaching the credit offset point; because, after spending perhaps more than two hours watching a film, who doesn’t want immediately want to start another?
Here’s the adblock rule you need:
(i.e. you’re blocking div.nextUpWrapper)
Lorna Jane started this off with a list of useful apps (Spectacle and Vimium in particular I’d recommend) and I’ve contributed some of the keyboard shortcuts I’ve picked up.